Wang Chunxu, Wang Lixin, Yang Wuli
Key Laboratory of Molecular Engineering of Polymers (Ministry of Education) and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
J Colloid Interface Sci. 2009 May 15;333(2):749-56. doi: 10.1016/j.jcis.2009.02.008. Epub 2009 Feb 10.
In this paper, a simple approach was presented to prepare functional inorganic/organic composite microspheres in which the inorganic nanoparticles were encapsulated into the polyelectrolyte complexes between chitosan (CS) and poly(aspartic acid) sodium salt (PAsp). The magnetic microspheres were prepared via electrostatic interaction between the citrate groups stabilizing Fe(3)O(4) nanoparticles and the amino groups of CS. Being taken as a kind of special polyelectrolyte with high molecular weight, the inorganic nanoparticles presented strong interaction with polyelectrolyte. By tuning the unit molar ratio of the opposite charged polyelectrolytes and the amount of Fe(3)O(4) nanoparticles, the structure of the composite microspheres could be controlled and the dimension of microspheres ranged from 110 nm to 320 nm. Then the approach was extended to prepare luminescent-magnetic CS-PAsp microspheres by encapsulated Fe(3)O(4) nanoparticles and CdTe quantum dots synchronously, which exhibited superior pH stability and remained strong photoluminescence properties after crosslinking. The CdTe-Fe(3)O(4)/CS-PAsp composite microspheres are potentially useful for further application in biolabeling and imaging.
本文提出了一种简单的方法来制备功能性无机/有机复合微球，其中无机纳米颗粒被包裹在壳聚糖（CS）和聚天冬氨酸钠盐（PAsp）之间的聚电解质复合物中。通过稳定Fe(3)O(4)纳米颗粒的柠檬酸基团与CS的氨基之间的静电相互作用制备磁性微球。作为一种具有高分子量的特殊聚电解质，无机纳米颗粒与聚电解质表现出强烈的相互作用。通过调节带相反电荷的聚电解质的单位摩尔比和Fe(3)O(4)纳米颗粒的量，可以控制复合微球的结构，微球尺寸范围为110纳米至320纳米。然后将该方法扩展到通过同时包裹Fe(3)O(4)纳米颗粒和CdTe量子点来制备发光磁性CS-PAsp微球，其表现出优异的pH稳定性，交联后仍保持强的光致发光性能。CdTe-Fe(3)O(4)/CS-PAsp复合微球在生物标记和成像方面具有潜在的进一步应用价值。
