颈上神经节切除术对大鼠体温及脂多糖诱导的发热反应的影响。

Effects of superior cervical ganglionectomy on body temperature and on the lipopolysaccharide-induced febrile response in rats.

作者信息

Romeo Horacio E, Tio Delia L, Taylor Anna N

机构信息

Department of Neurobiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1763, USA.

出版信息

J Neuroimmunol. 2009 Apr 30;209(1-2):81-6. doi: 10.1016/j.jneuroim.2009.01.027. Epub 2009 Feb 28.

DOI:10.1016/j.jneuroim.2009.01.027

PMID:19251325

Abstract

The involvement of the cervical sympathetic ganglia (SCG) on body temperature and during the occurrence of the induced febrile response was investigated in rats. Bilateral superior cervical gaglionectomy (SCGx) attenuated the daily dark-phase temperature compared to that of the sham-operated rats during the first 2 days post surgery. Body temperatures returned to pre-surgery levels by Day-3. Ten days after surgery, a febrile response was induced by lipopolysaccharide (LPS) immune challenge. SCGx significantly blunted the LPS-induced febrile response. These data suggest that obliteration of the cervical sympathetic peripheral innervation impairs the capability to produce an induced febrile response.

摘要

研究了大鼠颈交感神经节（SCG）在体温调节及诱发发热反应过程中的作用。双侧颈上神经节切除术（SCGx）后，与假手术组大鼠相比，术后前两天，大鼠每日暗期体温降低。术后第3天，体温恢复至术前水平。术后10天，通过脂多糖（LPS）免疫激发诱发发热反应。SCGx显著减弱了LPS诱导的发热反应。这些数据表明，颈交感神经外周神经支配的切断损害了诱发发热反应的能力。