Ploumis Avraam, Ponnappan Ravi K, Bessey Jason T, Patel Ravi, Vaccaro Alexander R
Department of Orthopaedics, Thomas Jefferson University, Philadelphia, PA, USA.
Spine J. 2009 Jul;9(7):530-6. doi: 10.1016/j.spinee.2009.01.008. Epub 2009 Feb 28.
Although there are several studies evaluating the necessity and efficacy of thromboprophylaxis after spinal trauma with or without spinal cord injury (SCI), to date there is no established standard of practice pertaining to this specific patient population with regards to venous thromboembolism (VTE) prophylaxis.
To reach a consensus opinion in the administration of thromboprophylaxis in both preoperative and postoperative care in the settings of spinal trauma and SCI.
A live survey on thromboprophylaxis after spinal surgery in the setting of trauma was conducted at a meeting among spine trauma surgeons.
Twenty-five spine surgeons (Neurosurgeons and Orthopedic surgeons), all members of the Spine Trauma Study Group, participated in a live survey in which they attempted to reach consensus pertaining to the management of deep vein thrombosis prophylaxis in patients with spine fractures (with and without a concomitant SCI). The consensus survey consisted of a 10-item questionnaire. Chi-square test was used for group comparisons in questionnaire responses.
Complete agreement was reached for the need of postoperative pharmacologic thromboprophylaxis in cervical spine injuries with SCI and anterior thoracolumbar procedures with or without SCI. Postoperative pharmacologic thromboprophylaxis after cervical spine injuries without SCI was agreed not to be needed. In cases of delayed surgery for patients with SCI, pharmacologic thromboprophylaxis was recommended to be started as soon as possible in the presurgical period. The optimal duration of pharmacologic VTE prophylaxis was determined to be 3 months. Only 53% agreement was noted for the withholding of preoperative chemical prophylaxis in cervical or thoracolumbar spinal injuries with SCI (and 68% without SCI). Only 80% of the surgeons agreed that postoperative pharmacologic thromboprophylaxis is needed after posterior thoracolumbar procedures in patients with or without SCI. The use of vena cava filter after SCI was not universally recommended.
Postoperative pharmacologic thromboprophylaxis was opined to be unnecessary in patients with cervical spine injuries without SCI, however, it is recommended for cervical spine trauma with SCI or anterior thoracolumbar procedures irrespective of SCI. Pharmacologic thromboprophylaxis was recommended to start preoperatively as soon as possible in SCI cases or in cases with surgical delay. Pharmacologic prophylaxis was recommended to be administered for at least 3 months postinjury. Although these recommendations met complete consensus by this group, individual patient factors should also be considered in determining optimal thromboprophylaxis in this patient population. Future research recommendations on thromboprophylaxis in spinal trauma are proposed.
尽管有多项研究评估了脊髓损伤(SCI)或未损伤的脊柱创伤后血栓预防的必要性和有效性,但迄今为止,对于这一特定患者群体的静脉血栓栓塞(VTE)预防,尚无既定的实践标准。
就脊柱创伤和脊髓损伤患者术前和术后护理中血栓预防的管理达成共识。
在一次脊柱创伤外科医生会议上,对创伤情况下脊柱手术后的血栓预防进行了现场调查。
25名脊柱外科医生(神经外科医生和骨科医生),均为脊柱创伤研究组成员,参与了一项现场调查,他们试图就脊柱骨折患者(伴有或不伴有脊髓损伤)深静脉血栓形成预防的管理达成共识。共识调查包括一份10项问卷。卡方检验用于问卷回答的组间比较。
对于伴有脊髓损伤的颈椎损伤以及伴有或不伴有脊髓损伤的前路胸腰椎手术,术后药物血栓预防的必要性达成了完全一致。对于无脊髓损伤的颈椎损伤,术后药物血栓预防被认为不需要。对于脊髓损伤患者的延迟手术,建议在术前尽快开始药物血栓预防。药物VTE预防的最佳持续时间确定为3个月。对于伴有脊髓损伤的颈椎或胸腰椎脊柱损伤(不伴有脊髓损伤的为68%),术前化学预防的停用仅得到53%的认同。只有80%的外科医生同意,无论有无脊髓损伤,胸腰椎后路手术后都需要进行术后药物血栓预防。脊髓损伤后使用腔静脉滤器并未得到普遍推荐。
对于无脊髓损伤的颈椎损伤患者,术后药物血栓预防被认为是不必要的,然而,对于伴有脊髓损伤的颈椎创伤或前路胸腰椎手术,无论有无脊髓损伤,均建议进行药物血栓预防。对于脊髓损伤病例或手术延迟的病例,建议在术前尽快开始药物血栓预防。建议在受伤后至少3个月进行药物预防。尽管这些建议在该组中达成了完全共识,但在确定该患者群体的最佳血栓预防措施时,也应考虑个体患者因素。提出了未来关于脊柱创伤血栓预防的研究建议。