Leong F T, Freeman L J, Keavney B D
Department of Cardiology, Papworth Hospital, Papworth Everad, Cambridge, UK.
Heart. 2009 Mar;95(6):442-7. doi: 10.1136/hrt.2006.105130.
Cardiovascular malformations are the most common type of birth defect. Currently, only a fraction of cases have associated causative factors and little is known about the aetiology of the rest. Despite this, our understanding of normal and abnormal heart development continues to grow, a number of recent discoveries even challenging long-held concepts. In this review, we highlight some of this new knowledge, emphasising aspects that may be of interest to the clinician.
心血管畸形是最常见的出生缺陷类型。目前，只有一小部分病例有相关的致病因素，其余病例的病因知之甚少。尽管如此，我们对正常和异常心脏发育的理解仍在不断加深，最近的一些发现甚至挑战了长期以来的观念。在这篇综述中，我们重点介绍了一些新知识，强调了临床医生可能感兴趣的方面。
