Kedziora Sylwia, Słotwiński Robert
Zakład Immunologii i Zywienia Wydziału Nauki o Zdrowiu, Warszawski Uniwersytet Medyczny, Poland.
Postepy Hig Med Dosw (Online). 2009 Feb 11;63:30-8.
Innate immunity is the fi rst line of the defensive mechanisms protecting the host from invading pathogens. Structures of pathogens called PAMPs (pathogen-associated molecular patterns) are recognized by extra- and intracellular pattern recognition receptors (PRRs), which includes three families of sensors: TLRs, NLRs, and RLRs. Knowledge of the mechanisms involving PRRs makes it possible to understand innate immune activity and the development of precise methods of preventing and treating infection at the molecular level. This article presents the molecular pathways initiated in response to pathogens.
固有免疫是保护宿主免受入侵病原体侵害的防御机制的第一道防线。被称为病原体相关分子模式（PAMPs）的病原体结构由细胞外和细胞内模式识别受体（PRRs）识别，PRRs包括三类传感器：Toll样受体（TLRs）、NOD样受体（NLRs）和视黄酸诱导基因I样受体（RLRs）。了解涉及PRRs的机制有助于理解固有免疫活性以及在分子水平上预防和治疗感染的精确方法的开发。本文介绍了针对病原体引发的分子途径。
