Wenham Claire Y J, Conaghan Philip G
Department of Rheumatology, Leeds Teaching Hospitals Trust, UK.
Nat Clin Pract Rheumatol. 2009 Mar;5(3):149-58. doi: 10.1038/ncprheum1023.
Pain in the peripheral joints is an increasingly common problem, resulting in significant patient disability and health-care expenditure. Osteoarthritis (OA), a syndrome of joint pain with associated structural changes, is the most prevalent joint disease, yet the etiology of pain in OA is not entirely clear. Traditional assessment of the structure-pain relationship in knee OA has relied on conventional radiography, which has several limitations, not least the discrepancy between symptoms and radiographic findings. MRI has the capability to visualize all the structures within the knee joint, and there is a growing body of work using MRI to examine the correlation between structural findings and symptoms. In large cohort studies, synovial hypertrophy, synovial effusions, and abnormalities in the subchondral bone have been associated with knee pain. Advances in our understanding of the etiology of pain in OA will assist in the identification of further targets for treatment of this common and painful disease.
外周关节疼痛是一个日益常见的问题，会导致患者严重残疾并产生大量医疗保健支出。骨关节炎（OA）是一种伴有相关结构变化的关节疼痛综合征，是最常见的关节疾病，然而OA疼痛的病因尚不完全清楚。传统上对膝关节OA结构与疼痛关系的评估依赖于传统X线摄影，其存在若干局限性，尤其是症状与X线表现之间的差异。MRI能够显示膝关节内的所有结构，并且利用MRI研究结构表现与症状之间相关性的研究工作越来越多。在大型队列研究中，滑膜增生、滑膜积液和软骨下骨异常与膝关节疼痛有关。我们对OA疼痛病因认识的进展将有助于确定治疗这种常见且疼痛疾病的更多靶点。
