CARD8与白细胞介素-6之间的基因-基因相互作用降低了阿尔茨海默病的风险。 - Suppr

Gene-gene interaction between CARD8 and interleukin-6 reduces Alzheimer's disease risk.

作者信息

Fontalba Ana, Gutiérrez Olga, Llorca Javier, Mateo Ignacio, Vázquez-Higuera José Luis, Berciano José, Fernández-Luna José Luis, Combarros Onofre

出版信息

J Neurol. 2009 Jul;256(7):1184-6. doi: 10.1007/s00415-009-5080-z. Epub 2009 Mar 1.

DOI:10.1007/s00415-009-5080-z

PMID:19252766

Abstract

摘要

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Gene-gene interaction between CARD8 and interleukin-6 reduces Alzheimer's disease risk.CARD8与白细胞介素-6之间的基因-基因相互作用降低了阿尔茨海默病的风险。

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Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer's disease: a meta-analysis.白细胞介素 6（-174 G/C）启动子区域多态性与阿尔茨海默病风险的关联：荟萃分析。

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Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):745-56. doi: 10.1002/ajmg.b.31043.

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J Immunol. 2007 Oct 1;179(7):4867-73. doi: 10.4049/jimmunol.179.7.4867.

TUCAN (CARD8) genetic variants and inflammatory bowel disease.TUCAN（CARD8）基因变异与炎症性肠病。

Gastroenterology. 2006 Oct;131(4):1190-6. doi: 10.1053/j.gastro.2006.08.008. Epub 2006 Aug 5.

Interaction between interleukin-6 and intercellular adhesion molecule-1 genes and Alzheimer's disease risk.白细胞介素-6与细胞间黏附分子-1基因之间的相互作用及阿尔茨海默病风险

J Neurol. 2005 Apr;252(4):485-7. doi: 10.1007/s00415-005-0658-6. Epub 2005 Mar 22.

Interleukin-6 in the aging brain.衰老大脑中的白细胞介素-6

J Neuroimmunol. 2004 Feb;147(1-2):141-4. doi: 10.1016/j.jneuroim.2003.10.031.

Neuroreport. 2002 Sep 16;13(13):1645-7. doi: 10.1097/00001756-200209160-00015.

Inflammation in neurodegenerative disease--a double-edged sword.神经退行性疾病中的炎症——一把双刃剑。

Neuron. 2002 Aug 1;35(3):419-32. doi: 10.1016/s0896-6273(02)00794-8.

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.CARD-8蛋白，一种调节半胱天冬酶-1激活和细胞凋亡的新型CARD家族成员。

J Biol Chem. 2002 Apr 19;277(16):13952-8. doi: 10.1074/jbc.M107811200. Epub 2002 Jan 30.

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.白细胞介素-6（IL-6）基因新型多态性对IL-6转录及血浆IL-6水平的影响，以及与全身型幼年慢性关节炎的关联。

J Clin Invest. 1998 Oct 1;102(7):1369-76. doi: 10.1172/JCI2629.

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease.转录因子NF-κB在原代神经元中被β-淀粉样肽激活，并且在阿尔茨海默病患者早期斑块周围的神经元中也被激活。

Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2642-7. doi: 10.1073/pnas.94.6.2642.

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Gene-gene interaction between CARD8 and interleukin-6 reduces Alzheimer's disease risk.

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