Dorsher C W, Rosenblatt J E, Wilson W R, Ilstrup D M
Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Rev Infect Dis. 1991 Jul-Aug;13(4):633-6. doi: 10.1093/clinids/13.4.633.
At the Mayo Clinic, the number of cases of anaerobic bacteremia decreased 45% between 1974 and 1988. In addition, the percentage of blood cultures positive for anaerobes decreased significantly even though the total number of blood cultures performed increased. The number of anaerobic bacteremias per 100,000 patient-days also declined over the 15-year period. Organisms of the Bacteroides fragilis group ranked third in frequency with respect to other organisms that caused aerobic and anaerobic bacteremia in 1974 but ranked only seventh in 1988 and caused slightly less than one-half of the anaerobic bacteremias. The mechanisms responsible for these changes are unclear but might relate to earlier recognition and treatment of localized anaerobic infection, widespread preoperative use of agents prior to bowel surgery, and use of broad-spectrum antimicrobial regimens that include agents with activity against anaerobes.
在梅奥诊所，1974年至1988年间厌氧菌血症病例数减少了45%。此外，尽管进行的血培养总数增加，但厌氧菌血培养阳性的百分比仍显著下降。每100,000患者日的厌氧菌血症数量在这15年期间也有所下降。脆弱拟杆菌群在导致需氧菌和厌氧菌血症的其他微生物中，1974年的出现频率排名第三，但在1988年仅排名第七，导致的厌氧菌血症略少于总数的一半。这些变化的原因尚不清楚，但可能与局部厌氧菌感染的早期识别和治疗、肠道手术前广泛使用药物以及使用包括对厌氧菌有活性的药物的广谱抗菌方案有关。
