Debeb Bisrat G, Xu Wei, Woodward Wendy A
Division of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
J Mammary Gland Biol Neoplasia. 2009 Mar;14(1):11-7. doi: 10.1007/s10911-009-9114-z. Epub 2009 Feb 28.
Meta-analyses of tens of thousands of women treated with radiation as a component of their breast cancer treatment have shown that radiation improves overall survival from breast cancer in women with early stage and advanced disease. However, data suggest that breast cancer stem/progenitor cells can be enriched after radiation and that breast cancer stem/progenitor clonogens are particularly resistant to radiation. Potentially resistant breast cancer stem/progenitor populations appear to be over-represented in estrogen receptor negative breast cancer and indeed, clinically these cancers are more resistant to radiation than estrogen receptor positive breast cancers. Emerging pre-clinical data suggest that targeting cancer stem/progenitor survival pathways may lead to effective radiosensitization in subgroups of patients with resistant disease. Herein, preclinical studies are reviewed in the context of the clinical framework.
对成千上万接受放疗作为乳腺癌治疗一部分的女性进行的荟萃分析表明，放疗可提高早期和晚期乳腺癌女性的总体生存率。然而，数据表明，放疗后乳腺癌干细胞/祖细胞会增多，且乳腺癌干细胞/祖细胞克隆原对放疗具有特别的抗性。雌激素受体阴性乳腺癌中潜在抗性的乳腺癌干细胞/祖细胞群体似乎占比过高，实际上，在临床上这些癌症比雌激素受体阳性乳腺癌对放疗更具抗性。新出现的临床前数据表明，靶向癌症干细胞/祖细胞存活途径可能会使耐药疾病亚组患者实现有效的放射增敏。在此，我们结合临床框架对临床前研究进行综述。
