Lambert J R
Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia.
Rev Infect Dis. 1991 Jul-Aug;13 Suppl 8:S691-5. doi: 10.1093/clinids/13.supplement_8.s691.
Bismuth compounds have been used for more than two centuries. A review of the modes of action, pharmacokinetics, and toxicity of two commonly used compounds, colloidal bismuth subcitrate and bismuth subsalicylate, is presented. In humans bismuth toxicity is unlikely when therapeutic doses of these compounds are administered for the appropriate duration. The recent use of bismuth compounds to eradicate infection with Helicobacter pylori and to prevent travelers' diarrhea has resulted in scientific reevaluation of these agents.
铋化合物已经被使用了两个多世纪。本文综述了两种常用化合物，即枸橼酸铋钾和碱式水杨酸铋的作用方式、药代动力学及毒性。在人类中，当以适当的疗程给予这些化合物的治疗剂量时，铋中毒不太可能发生。铋化合物最近用于根除幽门螺杆菌感染及预防旅行者腹泻，这使得对这些药物进行了科学的重新评估。
