伴有未确诊霍奇金淋巴瘤的霜样树枝状视网膜血管炎
Frosted branch angiitis with undiagnosed Hodgkin lymphoma.
作者信息
Hua Minh-Tri, Blaise Pierre, De Leval Laurence, Rakic Jean-Marie
机构信息
Department of Ophthalmology, Centre Hospitalier Universitaire de Liège, Liège - Belgium.
出版信息
Eur J Ophthalmol. 2009 Mar-Apr;19(2):310-3. doi: 10.1177/112067210901900226.
PURPOSE
To report the case of a patient with bilateral frosted branch angiitis and undiagnosed Hodgkin lymphoma.
METHODS
Review of clinical history, laboratory findings, histology of supraclavicular lymph node biopsy, and follow-up.
RESULTS
A 22-year-old man presented with a sudden, bilateral visual loss. Fundus examination and fluorescein angiography disclosed a bilateral frosted branch angiitis that was dramatically responsive to systemic corticosteroid therapy. Laboratory tests were unremarkable but radiologic studies showed extensive mediastinal and supraclavicular lymphadenopathy. A supraclavicular lymph node biopsy led to the diagnosis of nodular sclerosis Hodgkin lymphoma.
CONCLUSIONS
The occurrence of frosted branch angiitis in combination with classical Hodgkin lymphoma, although possibly coincidental, raises the possibility of a paraneoplastic syndrome. Thus, we suggest that, for patients with frosted branch angiitis, Hodgkin lymphoma should be considered in the diagnostic workup.
目的
报告一例双侧霜样树枝状视网膜血管炎合并未确诊霍奇金淋巴瘤的患者。
方法
回顾临床病史、实验室检查结果、锁骨上淋巴结活检组织学检查及随访情况。
结果
一名22岁男性突发双侧视力丧失。眼底检查和荧光素血管造影显示双侧霜样树枝状视网膜血管炎，对全身糖皮质激素治疗反应显著。实验室检查无异常，但影像学研究显示广泛的纵隔和锁骨上淋巴结肿大。锁骨上淋巴结活检确诊为结节硬化型霍奇金淋巴瘤。
结论
霜样树枝状视网膜血管炎与经典霍奇金淋巴瘤同时出现，虽可能为巧合，但提示副肿瘤综合征的可能性。因此，我们建议，对于患有霜样树枝状视网膜血管炎的患者，在诊断检查中应考虑霍奇金淋巴瘤。
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