Lee Chi-Hoon, Kim Hyung-Wook, Lee Hoi-Seon
Department of Agricultural Chemistry and Institute of Agricultural Science and Technology, College of Agriculture and Life Sciences, Chonbuk National University, Chonju, South Korea.
Pest Manag Sci. 2009 Jun;65(6):704-10. doi: 10.1002/ps.1728.
Piperazine derivatives possess pharmacological properties, yet the acaricidal activity of these compounds has not been investigated. This study was conducted to evaluate the colour alteration and acaricidal activity of piperazine derivatives against Dermatophagoides spp. and Tyrophagus putrescentiae (Schrank) using filter paper and fumigant methods.
In a fumigant bioassay, 1-phenylpiperazine (7.83 microg cm(-2)) against D. farinae (Hughes) was found to be 4.7 times more toxic than DEET (36.84 microg cm(-2)), followed by benzyl benzoate (9.72 microg cm(-2)), piperazine (11.41 microg cm(-2)), 1-ethoxycarbonylpiperazine (20.14 microg cm(-2)) and 1-(2-methoxyphenyl)piperazine (22.14 microg cm(-2)). In a filter paper bioassay, 1-(2-methoxyphenyl)piperazine (3.65 microg cm(-2)) was 5.7 times more toxic than DEET (20.64 microg cm(-2)), followed by 1-ethoxycarbonylpiperazine (4.02 microg cm(-2)), 1-phenylpiperazine (4.75 microg cm(-2)), benzyl benzoate (7.83 microg cm(-2)) and piperazine (10.59 microg cm(-2)). Similar results have been exhibited with piperazine derivatives against D. pteronyssinus (Troussart). However, no activity against T. putrescentiae was observed for piperazine derivatives, except for piperazine.
These results indicate that piperazine derivatives may be suitable as vapour-phase acaricide fumigants owing to their high volatility, acaricidal activity and safety. 1-Phenylpiperazine was found to be an excellent mite indicator based on the colour change it induced. Taken together, these findings indicate that piperazine derivatives may be used to replace existing problematical acaricides owing to their activity and ability to act as a mite indicator.
哌嗪衍生物具有药理特性，但这些化合物的杀螨活性尚未得到研究。本研究旨在使用滤纸法和熏蒸法评估哌嗪衍生物对嗜皮螨属和腐食酪螨（Schrank）的颜色变化及杀螨活性。
在熏蒸生物测定中，发现1-苯基哌嗪（7.83微克/平方厘米）对粉螨（Hughes）的毒性比避蚊胺（36.84微克/平方厘米）高4.7倍，其次是苯甲酸苄酯（9.72微克/平方厘米）、哌嗪（11.41微克/平方厘米）、1-乙氧羰基哌嗪（20.14微克/平方厘米）和1-（2-甲氧基苯基）哌嗪（22.14微克/平方厘米）。在滤纸生物测定中，1-（2-甲氧基苯基）哌嗪（3.65微克/平方厘米）的毒性比避蚊胺（20.64微克/平方厘米）高5.7倍，其次是1-乙氧羰基哌嗪（4.02微克/平方厘米）、1-苯基哌嗪（4.75微克/平方厘米）、苯甲酸苄酯（7.83微克/平方厘米）和哌嗪（10.59微克/平方厘米）。哌嗪衍生物对柏氏禽刺螨（Troussart）也表现出类似结果。然而，除哌嗪外，未观察到哌嗪衍生物对腐食酪螨有活性。
这些结果表明，哌嗪衍生物因其高挥发性、杀螨活性和安全性，可能适合作为气相杀螨熏蒸剂。基于其引起的颜色变化，发现1-苯基哌嗪是一种优良的螨虫指示剂。综上所述，这些发现表明，哌嗪衍生物因其活性和作为螨虫指示剂的能力，可用于替代现有的有问题的杀螨剂。
