Wu Xuan, Xu Geng, Wen Weiping, Guo Jiebo
Hospital of Otolaryngology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Dec;22(23):1060-2, 1067.
To study the clinical diagnosis, course and combined therapy of aggressive rhinocerebral mucormycosis.
The clinical feature, diagnosis and therapy were analyzed in 5 cases with rhinocerebral mucormycosis throughout disease progress. Good treatments were found by analyzing curative effect of different treatment.
One patient died within three weeks in hospital three patients survived from 2 months to 2 years; and one patient was alive over 3 years. The mortality rate was 80% in this study.
Rhinocerebral mucormycosis is always secondary to patients with severe diseases and bad immunologic function. The lesion can invade the orbit and brain quickly, and the mortality rate is high. The cause of the disease can be retarded by clearing up the focus early and removing the environment of fungi thriving with combined therapy. It is effective of remodelling the necrotic tissues by nasal endoscopy.
研究侵袭性鼻脑型毛霉菌病的临床诊断、病程及综合治疗方法。
对5例鼻脑型毛霉菌病患者在疾病全过程中的临床特征、诊断及治疗进行分析。通过分析不同治疗方法的疗效找到较好的治疗方案。
1例患者在住院3周内死亡，3例患者存活2个月至2年，1例患者存活超过3年。本研究的死亡率为80%。
鼻脑型毛霉菌病常继发于重症及免疫功能差的患者。病变可迅速侵犯眼眶及脑，死亡率高。早期清除病灶并采用综合治疗消除真菌滋生环境可延缓病情发展。鼻内镜下对坏死组织进行重塑有效。
