Charfi S, Chetaille B, Marcy M, Turrini O, Chaise De Maison C, Delpero J R, Viret F, Xerri L, Monges G
Department biopathology, Paoli-Calmettes Institute, 232 Bd St-Marguerite, 13273, Marseille, Cedex 9, France.
Pathologica. 2008 Oct;100(5):416-9.
Multicystic peritoneal mesothelioma is a rare lesion occurring mainly in women in a reproductive age. Its pathogenesis is unclear. We report three cases of multicystic peritoneal mesothelioma in patients that were 28, 38 and 47 years of age (one male, two females). A history of abdominal surgery was reported in two cases. Explorative laparotomy was presumptive of a pseudomyxoma peritoni in two cases, and hyperthermic intraperitoneal chemotherapy was performed. Histological examination demonstrated multicystic lesions with mesothelial cells lining confirmed by immunohistochemical analysis. Unusual findings such as hyperplasia, hobnail features, cytoplasmic vacuolisation and papillary pattern were occasionally noted. The clinical presentation, pathogenesis and pathologic features including differential diagnosis of multicystic peritoneal mesothelioma are discussed.
多囊性腹膜间皮瘤是一种罕见病变，主要发生于育龄女性。其发病机制尚不清楚。我们报告了3例多囊性腹膜间皮瘤患者，年龄分别为28岁、38岁和47岁（1例男性，2例女性）。2例患者有腹部手术史。2例患者经剖腹探查初步诊断为腹膜假黏液瘤，并进行了腹腔内热化疗。组织学检查显示有多囊性病变，免疫组化分析证实内衬间皮细胞。偶尔可见增生、鞋钉样特征、细胞质空泡化和乳头状模式等异常表现。本文讨论了多囊性腹膜间皮瘤的临床表现、发病机制和病理特征，包括鉴别诊断。
