Cesaro P, Degos J D
Service de neurologie, hôpital Henri Mondor, Créteil.
Rev Prat. 1991 Sep 15;41(20):1893-7.
Clinical manifestations of multiple sclerosis cannot be exactly correlated with lesions identified by brain imaging, electrophysiology or even anatomy. It is generally accepted that a continuous conduction is possible within some demyelinated fibers, and a conduction block may occur in the CNS white matter without demyelinization. These data explain the possible occurrence of brief, repetitive deficits besides the classical relapses. Among the latter, at least some are not correlated with demyelinization. The knowledge of these mechanisms suggest the possibility of therapy to restore the conduction without a direct action on the demyelinating process.
多发性硬化症的临床表现与通过脑成像、电生理学甚至解剖学所确定的病变不能完全相关。人们普遍认为，在一些脱髓鞘纤维内可能存在连续传导，并且在没有脱髓鞘的中枢神经系统白质中可能会出现传导阻滞。这些数据解释了除经典复发之外短暂、重复性缺陷可能出现的原因。在后者中，至少有一些与脱髓鞘无关。对这些机制的了解提示了在不对脱髓鞘过程进行直接作用的情况下恢复传导的治疗可能性。
