Harrer G
Psychiatr Neurol Med Psychol (Leipz). 1986 Feb;38(2):77-85.
The type and extent of neurological deficits in multiple sclerosis depends on the localisation and size of the lesion and the type of neuropathological pattern of the lesion. The elective demyelinating process (loss of myeline sheath without axonal damage) brings, about a showing and faulty conduction of impulses and thereby a disturbed processing of information. It can finally come to a total (functional, reversible) conduction blockage. Additionally also disturbances in the synaptic transmission may be involved. The occurrence and extent of these disturbances in conduction and transmission depend on definite paristatic factors. Our presented concepts of the "therapeutic model" based on pathophysiological investigations in multiple sclerosis show the tendency towards a "marked symptomatic therapy", which does not however, influence the basis of the disease processes, but rather represents an extremely helpful suppression of symptoms for the patients concerned.
多发性硬化症中神经功能缺损的类型和程度取决于病变的位置、大小以及病变的神经病理学模式类型。选择性脱髓鞘过程（髓鞘丢失而无轴突损伤）导致冲动传导显示异常和错误，从而干扰信息处理。最终可能导致完全（功能性、可逆性）传导阻滞。此外，突触传递也可能受到干扰。这些传导和传递干扰的发生和程度取决于特定的病理因素。我们基于多发性硬化症病理生理学研究提出的“治疗模型”概念显示出一种“显著对症治疗”的趋势，然而，这并不会影响疾病进程的基础，而是对相关患者的症状起到极其有效的抑制作用。
