Zhao Zhen, Li Fang-lan, Zhao Li-xia, Su Ming-gang
Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):1036-9.
The aim of the study was to evaluate the value of the single photon emission computed tomography/computed tomography (SPECT/CT) fusion imaging in the diagnosis of benign and malignant lesions in bones.
One hundred and forty one bone lesions of 125 cancer patients, for whom the natures of the lesions were not able to be determined by the 99Tc(m)-MDP whole-body bone scan, were examined by the SPECT, CT and SPECT/CT fusion imaging simultaneously. All of the images were blindly interpreted independently by two experienced nuclear medicine physicians. The natures of the lesions were eventually confirmed by MRI, pathology or follow-up diagnosis six months later.
The diagnostic sensitivity of SPECT, SPECT+CT and SPECT/CT for the 141 bone lesions was 82.5%, 93.7%, and 98.4% respectively. The specificity was 66.7%, 80.8%, and 93.6% respectively. The accuracy was 73.8%, 86.5%, and 95.7% respectively. The specificity and accuracy of SPECT/CT for diagnosing bone lesions were significantly higher than those of SPECT and SPECT+CT (P<0.05).
SPECT/CT can effectively differentiate benign and malignant bone lesions.
本研究旨在评估单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）融合成像在骨良性和恶性病变诊断中的价值。
对125例癌症患者的141处骨病变进行研究，这些病变通过99Tc（m）-MDP全身骨扫描无法确定其性质，同时采用SPECT、CT和SPECT/CT融合成像进行检查。所有图像由两位经验丰富的核医学医师独立进行盲法解读。病变性质最终通过MRI、病理检查或6个月后的随访诊断得以确认。
SPECT、SPECT+CT和SPECT/CT对141处骨病变的诊断敏感性分别为82.5%、93.7%和98.4%。特异性分别为66.7%、80.8%和93.6%。准确性分别为73.8%、86.5%和95.7%。SPECT/CT诊断骨病变的特异性和准确性显著高于SPECT和SPECT+CT（P<0.05）。
SPECT/CT能够有效鉴别骨良性和恶性病变。
