Gourdet Benoit, Lam Hon Wai
School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, United Kingdom.
J Am Chem Soc. 2009 Mar 25;131(11):3802-3. doi: 10.1021/ja900946h.
A new rhodium-catalyzed carbozincation of ynamides has been developed, using diorganozinc reagents or functionalized alkylzinc halides. The reactions are highly regio- and stereoselective, allowing access to a wide range of multisubstituted enamides, which are increasingly important building blocks for organic synthesis. Utilization of the alkenylzinc intermediates in further carbon-carbon bond-forming reactions to form trisubstituted enamides is also possible.
已开发出一种新的铑催化的烯酰胺碳锌化反应，该反应使用二有机锌试剂或官能化的卤代烷基锌。这些反应具有高度的区域选择性和立体选择性，能够合成多种多取代的烯酰胺，而多取代烯酰胺是有机合成中越来越重要的结构单元。利用烯基锌中间体进行进一步的碳-碳键形成反应以生成三取代烯酰胺也是可行的。
