用于手性2-酰胺基苯并呋喃合成的铑（I）催化的邻甲氧基苯取代的烯炔酰胺的去甲基化环化反应。
A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans.
作者信息
Oppenheimer Jossian, Johnson Whitney L, Tracey Michael R, Hsung Richard P, Yao Pei-Yuan, Liu Renhe, Zhao Kang
机构信息
Division of Pharmaceutical Sciencies and Department of Chemistry, University of Wisconsin-Madison, Rennebohm Hall, 777 Highland Avenue, Madison, Wisconsin 53705-2222, USA.
出版信息
Org Lett. 2007 Jun 7;9(12):2361-4. doi: 10.1021/ol0707362. Epub 2007 May 10.
PMID:17489599
Abstract
A Rh(I)-catalyzed demethylation-cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step.
摘要
本文描述了一种铑（I）催化的去甲基化-环化序列反应，可将邻甲氧基取代的炔酰胺直接转化为苯并呋喃。银盐与铑（I）协同作用，促进关键的去甲基化步骤。
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