Kovacs K, Horvath E, Singer W, Lilienfield H
Endokrinologie. 1977 Feb;69(1):94-102.
A 49-year-old man with pancreatic adenocarcinoma, suggestive of islet cell origin, showed clinical and biochemical features of ectopic ACTH syndrome and underwent bilateral adrenalectomy. Light microscopy revealed adrenocortical compact cell hyperplasia and lipid depletion. The zona glomerulosa was detected in small foci and fasciculata cells extended up to the capsule. Electron microscopy disclosed enlargement of adrenocortical cells, massive SER accumulation, RER increase, lipid depletion, prominence of the Golgi apparatus and development of complex interdigitations between closely apposed cell membranes. These changes were attributed to the stimulative effect of ACTH discharged from the non-pituitary tumor. Mitochondria exhibited enlargement, pleomorphism and cavitation. Most of the adrenocortical cells contained mitochondria with vesicular cristae--a characteristic feature of fasciculata cells. In a few cells, under the capsule, some mitochondria possessed lamellar cristae. Gradual transformation to the vesicular type was, however, apparent indicating that mitochondria are not rigidly constant structures.
一名49岁的男性，患有胰岛细胞起源的胰腺腺癌，表现出异位促肾上腺皮质激素（ACTH）综合征的临床和生化特征，并接受了双侧肾上腺切除术。光镜检查显示肾上腺皮质致密细胞增生和脂质耗竭。在小灶性区域检测到球状带，束状带细胞延伸至被膜。电镜检查发现肾上腺皮质细胞增大，滑面内质网大量积聚，粗面内质网增加，脂质耗竭，高尔基体突出，相邻细胞膜之间出现复杂的指状交叉。这些变化归因于非垂体肿瘤分泌的ACTH的刺激作用。线粒体表现为增大、多形性和空泡化。大多数肾上腺皮质细胞含有具有泡状嵴的线粒体——这是束状带细胞的特征性表现。在被膜下的少数细胞中，一些线粒体具有板层嵴。然而，逐渐向泡状类型的转变很明显，表明线粒体不是严格恒定的结构。
