Tanaka Yasuhito, Takakura Yoshinori, Kumai Tsukasa, Sugimoto Kazuya, Taniguchi Akira, Hattori Koji
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, 634-8522, Japan.
Foot Ankle Int. 2009 Feb;30(2):128-32. doi: 10.3113/FAI-2009-0128.
We devised a method of sclerotherapy using OK432. The present study comprised a retrospective followup of sclerotherapy outcomes.
Eighteen feet in 18 consecutive patients (seven men, 11 women; mean age, 55 years) were treated with sclerotherapy. Previous surgery had been performed one to four times for seven feet. After aspirating the contents of the ganglion cysts, 0.2 to 0.3 ml of suspension of OK432 (lyophilized strep pyogenes) was injected. The volume of fluid aspirated was from 0.2 to 2.5 ml, with an average of 0.9 ml. Mean duration of followup was 3 years 6 months. Clinical evaluation was performed using the AOFAS hallux scale.
All ganglion cysts disappeared after sclerotherapy. However, recurrences were observed in eight feet. Mean duration until recurrence was 13 months. Sclerotherapy was again performed for all patients with recurrence. Re-recurrence occurred in three feet. A third sclerotherapy was performed for all three patients. All ganglion cysts had disappeared by final followup. Mean AOFAS score improved from 75 points before therapy to 95 points at followup. Six patients had complications with local redness and pain for 1 to 6 days after injection.
Sclerotherapy using OK432 is a minimally invasive treatment of symptomatic ganglion cysts of the hallux. Recurrence is common but complications are infrequent and self-limited.
我们设计了一种使用OK432进行硬化治疗的方法。本研究包括对硬化治疗结果的回顾性随访。
连续18例患者(7例男性,11例女性;平均年龄55岁)的18只足接受了硬化治疗。7只足曾接受过1至4次手术。抽吸腱鞘囊肿内容物后,注射0.2至0.3 ml OK432(冻干化脓性链球菌)悬液。抽吸的液体量为0.2至2.5 ml,平均为0.9 ml。平均随访时间为3年6个月。使用美国足踝外科协会(AOFAS)拇趾评分进行临床评估。
硬化治疗后所有腱鞘囊肿均消失。然而,8只足出现复发。复发的平均时间为13个月。对所有复发患者再次进行硬化治疗。3只足再次复发。对这3例患者均进行了第三次硬化治疗。至最终随访时所有腱鞘囊肿均消失。AOFAS平均评分从治疗前的75分提高至随访时的95分。6例患者在注射后1至6天出现局部发红和疼痛的并发症。
使用OK432进行硬化治疗是拇趾有症状腱鞘囊肿的一种微创治疗方法。复发常见,但并发症少见且为自限性。