铁感知作为一种伙伴关系：遗传性血色素沉着症蛋白（HFE）与转铁蛋白受体2

Iron sensing as a partnership: HFE and transferrin receptor 2.

作者信息

Fleming Robert E

机构信息

Saint Louis University School of Medicine, St. Louis, MO 63104, USA.

出版信息

Cell Metab. 2009 Mar;9(3):211-2. doi: 10.1016/j.cmet.2009.02.004.

DOI:10.1016/j.cmet.2009.02.004

PMID:19254564

Abstract

The mechanism by which HFE participates in the regulation of iron homeostasis has remained enigmatic. Gao et al. (2009) make the key discovery that the regulation of hepcidin in response to holotransferrin requires the interaction between HFE and transferrin receptor 2 (TfR2).

摘要

HFE参与铁稳态调节的机制一直不明。高等人（2009年）有一项关键发现，即铁调素对全转铁蛋白的应答调节需要HFE与转铁蛋白受体2（TfR2）之间的相互作用。