Ganz Tomas
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1690, USA.
Cell Metab. 2008 Apr;7(4):288-90. doi: 10.1016/j.cmet.2008.03.008.
Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.
在此，着重介绍了近期对铁稳态的见解。三项研究表明，IRE-IRP系统对于肠上皮细胞在平衡细胞外铁需求与细胞内铁需求方面具有重要性，表明血色素沉着症蛋白HFE主要通过调节铁调素的产生在肝细胞中发挥其铁调节活性，并为通过全转铁蛋白将HFE从转铁蛋白受体1上置换下来所引发的信号级联反应来转录调节铁调素的 proposed 机制提供了有力支持。 （注：原文中“proposed”翻译为“提出的”，这里为了保持原文结构完整性保留英文未翻译，需根据实际情况补充完整含义）
