Michigan State University, East Lansing, Michigan 48824, USA.
Heart Lung. 2009 Mar-Apr;38(2):141-50. doi: 10.1016/j.hrtlng.2008.05.001. Epub 2008 Sep 30.
Patients with chronic obstructive pulmonary disease (COPD) experience significant impairment in their quality of life (QOL). However, relatively few studies have examined overall and global QOL in patients with COPD using both generic QOL and health-related quality of life (HRQOL) measures.
The purposes of this pilot study were to describe the self-reported QOL (overall and global), disease-specific HRQOL, depressive symptoms, and disease-specific symptoms and experiences of patients with COPD and to examine the relationship among disease-specific HRQOL, depressive symptoms, disease-specific symptoms and experiences, and QOL (overall and global) in patients diagnosed with moderate to severe COPD.
A descriptive correlational design was used. Thirty-six participants completed overall QOL, global QOL, disease-specific HRQOL, depressive symptoms, and disease-specific symptoms and experiences questionnaires.
Overall QOL was low; global QOL was at the median of scale range. Overall QOL scores were significantly correlated with the disease-specific St George Respiratory Questionnaire total score, symptoms and impact subscale, depressive symptoms, and 7 Bronchitis Emphysema Symptom Checklist subscales.
Findings provided partial support for the association between QOL and disease-specific HRQOL and the usefulness of disease-specific questionnaires when assessing QOL.
慢性阻塞性肺疾病（COPD）患者的生活质量（QOL）会受到显著影响。然而，使用通用 QOL 和健康相关的生活质量（HRQOL）测量方法，评估 COPD 患者整体和全球 QOL 的研究相对较少。
本研究的目的是描述 COPD 患者的自我报告的 QOL（整体和全球）、疾病特异性 HRQOL、抑郁症状、疾病特异性症状和体验，并探讨疾病特异性 HRQOL、抑郁症状、疾病特异性症状和体验与中重度 COPD 患者的 QOL（整体和全球）之间的关系。
采用描述性相关设计。36 名参与者完成了整体 QOL、全球 QOL、疾病特异性 HRQOL、抑郁症状和疾病特异性症状和体验问卷。
整体 QOL 较低；全球 QOL 处于量表范围的中位数。整体 QOL 评分与疾病特异性圣乔治呼吸问卷总分、症状和影响子量表、抑郁症状以及 7 个支气管炎肺气肿症状检查表子量表显著相关。
研究结果部分支持 QOL 与疾病特异性 HRQOL 之间的关联，以及在评估 QOL 时使用疾病特异性问卷的有效性。
