Gerber A U
Medizinische Abteilung, Regionalspital Burgdorf.
Schweiz Med Wochenschr. 1991 Sep 28;121(39):1408-12.
Theoretical and experimental arguments favor administration of aminoglycosides once daily (q.d.). Results of clinical studies with a limited number of patients support these arguments. However, some practical and clinical questions remain unanswered. Therefore, q.d. infusion of aminoglycosides must still be considered experimental and must remain in the hands of infectious disease specialists until the results of ongoing clinical studies yield the ultimate proof that this novel dosing schedule is as efficacious and no more toxic than the conventional dosing regimens.
理论和实验依据支持每日一次（q.d.）给予氨基糖苷类药物。针对少数患者的临床研究结果支持了这些依据。然而，一些实际和临床问题仍未得到解答。因此，每日一次输注氨基糖苷类药物仍必须被视为试验性的，并且必须仍由传染病专家掌握，直到正在进行的临床研究结果给出最终证据，证明这种新的给药方案与传统给药方案一样有效且毒性不更大。
