Braunewell Stefan, Bornholdt Stefan
Institute for Theoretical Physics, University of Bremen, D-28359 Bremen, Germany.
J Theor Biol. 2009 Jun 21;258(4):502-12. doi: 10.1016/j.jtbi.2009.02.013. Epub 2009 Feb 28.
The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the repressilator, we discuss concepts of reliability of rhythmic attractors. In a simple evolution process we investigate how overall network structure affects the reliability of the dynamics. In the course of the evolution, networks are selected for reliable dynamics. We find that most networks can be easily evolved towards reliable functioning while preserving the original function.
在具有连续时间和噪声的广义布尔网络模型框架下，研究了生物调节网络中动力学的可靠性问题。利用诸如抑制器等著名的人工遗传网络，我们讨论了节律吸引子可靠性的概念。在一个简单的进化过程中，我们研究了整体网络结构如何影响动力学的可靠性。在进化过程中，选择具有可靠动力学的网络。我们发现，大多数网络在保持原始功能的同时，可以很容易地进化到可靠运行状态。
