Hess Karl, Goad Jeffery, Wu Joanne, Johnson Kathleen
College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA.
J Am Coll Health. 2009 Mar-Apr;57(5):553-5. doi: 10.3200/JACH.57.5.553-556.
The authors' objective was to document 9-month and previously recommended 6-month treatment completion rates for latent tuberculosis infection (LTBI) in a pharmacist-managed LTBI clinic in a community pharmacy on a college campus, and to describe patient characteristics.
Participants were university students diagnosed with LTBI.
The authors conducted a retrospective review of pharmacy records from 2000 to 2006. Main outcome measures included 6-month and 9-month LTBI treatment completion rates, total isoniazid (INH) tablets taken, characteristics of completers versus noncompleters, average time to treatment completion, and reported adverse drug events.
The 9-month completion rate was 59%, and the 6-month completion rate was 67%. Among those not completing treatment, 15.2% experienced fatigue and 2.2% experienced a rash (p=.04 and p=.03, respectively).
LTBI clinics are a unique niche for community pharmacies and can provide individualized patient care to ensure LTBI treatment adherence, monitoring for disease progression, and safety of INH.
作者的目的是记录大学校园社区药房中由药剂师管理的潜伏性结核感染（LTBI）诊所9个月及之前推荐的6个月治疗完成率，并描述患者特征。
参与者为被诊断患有LTBI的大学生。
作者对2000年至2006年的药房记录进行了回顾性审查。主要结局指标包括6个月和9个月的LTBI治疗完成率、服用异烟肼（INH）片剂总数、完成治疗者与未完成治疗者的特征、治疗完成的平均时间以及报告的药物不良事件。
9个月的完成率为59%，6个月的完成率为67%。在未完成治疗的患者中，15.2%出现疲劳，2.2%出现皮疹（p值分别为0.04和0.03）。
LTBI诊所是社区药房的一个独特领域，可为患者提供个性化护理，以确保LTBI治疗的依从性、疾病进展监测以及INH的安全性。
