Freeman Andrew J, Youngstrom Eric A, Michalak Erin, Siegel Rebecca, Meyers Oren I, Findling Robert L
University of North Carolina, Department of Psychology, CB3270, Davie Hall, Chapel Hill, NC 27599-3270, USA.
Pediatrics. 2009 Mar;123(3):e446-52. doi: 10.1542/peds.2008-0841.
Bipolar disorder is a common mood disorder associated with significant disability and impairment in quality of life in adults. Little research has examined the impact of the disorder on quality of life in children and adolescents. The current study examines the quality of life in children and adolescents with bipolar disorder compared with other physical and psychiatric illnesses.
This study included 529 youth and caregiver pairs who sought services at a community mental health center or an academic medical center. Diagnoses were based on semistructured interviews of caregivers and youths, and quality of life was determined by the parent-reported Revised Children Quality of Life Questioinnaire (KINDL) questionnaire and compared with published benchmarks for many medical illnesses.
Mean age of the youths was 12.0 years, 57% were boys, 72% were black, 22% were white, and 17% had received bipolar disorder diagnoses. Youths with bipolar disorder had significantly lower quality-of-life scores than youths with asthma, atopic dermatitis, obesity, arthritis, oxygen dependence, heart surgery during infancy, depression, behavior disorders, and nonmood and nonbehavior psychiatric diagnoses.
Youths with bipolar disorder reported lower quality of life than other youths encountered in pediatric practice. Pediatricians should attend not only to the child's mood symptoms but also to the overall impairment of the disorder.
双相情感障碍是一种常见的情绪障碍，与成年人的严重残疾和生活质量受损相关。很少有研究探讨该障碍对儿童和青少年生活质量的影响。本研究比较了双相情感障碍儿童和青少年与其他躯体疾病和精神疾病患者的生活质量。
本研究纳入了529对在社区心理健康中心或学术医疗中心寻求服务的青少年及其照料者。诊断基于对照料者和青少年的半结构化访谈，生活质量由父母报告的修订版儿童生活质量问卷（KINDL）确定，并与许多医学疾病已发表的基准进行比较。
青少年的平均年龄为12.0岁，57%为男孩，72%为黑人，22%为白人，17%被诊断为双相情感障碍。与患有哮喘、特应性皮炎、肥胖症、关节炎、依赖氧气、婴儿期心脏手术、抑郁症、行为障碍以及非情绪和非行为精神疾病诊断（的青少年相比），双相情感障碍青少年的生活质量得分显著更低。
双相情感障碍青少年报告的生活质量低于儿科实践中遇到的其他青少年。儿科医生不仅应关注儿童的情绪症状，还应关注该障碍的整体损害情况。
