Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Department of Psychiatry and Behavioral Neurosciences, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
J Child Adolesc Psychopharmacol. 2023 Aug;33(6):225-231. doi: 10.1089/cap.2023.0002.
Depression associated with bipolar disorder (BD) is more common compared to mania. Cognitive, family, and quality-of-life (QOL) factors associated with pediatric bipolar depression are understudied. The goal of this study was to evaluate cognitive, family environmental, and QOL characteristics of youth with bipolar depression. Thirty-two youth (12-18 years of age) with BD type I currently depressed were recruited from inpatient and outpatient setting. Subjects were assessed using the Behavior Rating Inventory of Executive Function (BRIEF), the Family Environment Scale (FES), and the Child Health Questionnaire-Parental-Form 50 (CHQ-PF50). Results were compared with population norms and the relationship between these domains was calculated. Youth with depression associated with BD did not show significant impairment in executive functions. They displayed impaired family environment in the domains of cohesion, independence, achievement orientation, and organization. Youth also displayed impairments in the psychosocial health domains compared with the population normative data. The CHQ-Psychosocial health significantly negatively correlated with the BRIEF-Global Executive Control score ( = -0.76, < 0.0001). Depression in youth with BD is associated with impairments in family functioning and QOL. Impairments in psychosocial QOL are associated with cognitive functioning. Further intervention studies examining executive functioning and family environment as treatment targets are needed. ClinicalTrials.gov identifier:NCT00232414.
与双相情感障碍（BD）相关的抑郁症比躁狂症更为常见。与儿科双相情感障碍相关的认知、家庭和生活质量（QOL）因素研究较少。本研究的目的是评估患有双相情感障碍的青少年的认知、家庭环境和生活质量特征。
从住院和门诊环境中招募了 32 名患有 I 型 BD 且目前处于抑郁状态的青少年。使用行为评定量表的执行功能（BRIEF）、家庭环境量表（FES）和儿童健康问卷-父母形式 50 分（CHQ-PF50）对受试者进行评估。将结果与人群正常值进行比较，并计算这些领域之间的关系。
患有与 BD 相关的抑郁症的青少年在执行功能方面没有明显的损伤。他们在凝聚力、独立性、成就取向和组织等领域的家庭环境受损。与人群正常值相比，青少年在心理健康领域也存在障碍。CHQ 心理健康状况与 BRIEF 全局执行控制评分显著负相关（ = -0.76， < 0.0001）。
BD 青少年的抑郁与家庭功能和生活质量受损有关。心理社会生活质量受损与认知功能有关。需要进一步进行干预研究，以检查执行功能和家庭环境作为治疗目标。临床试验标识符：NCT00232414。
