Psychas Vassilios, Loukopoulos Panayiotis, Polizopoulou Zoe S, Sofianidis Georgios
Pathology Laboratory, Faculty of Veterinary Medicine, Aristotle University, 54124 Thessaloniki, Greece.
J Vet Sci. 2009 Mar;10(1):81-3. doi: 10.4142/jvs.2009.10.1.81.
Multilobular tumour of bone (MTB) is an uncommon tumour and is usually located in the skull. A 13-year-old mixed breed dog was presented with a two-week history of progressively worsening vestibular dysfunction and cognitive abnormalities; it appeared demented and showed asymmetric ataxia and hypermetria of all limbs. The owner opted to have the animal euthanised. Necropsy revealed a large mass occupying the right occipital, parietal and temporal bones, severely compressing the cerebellum and the right occipital lobe. Histologically, it was characterised by the presence of multiple lobules containing osteoid or cartilage and separated by fibrous septae, features typical of MTB. Lung metastases were evident. To our knowledge, this is the first report of an MTB causing both severe cerebral and cerebellar compression and the second detailed report of an MTB of the occipital bone. MTB should be included in the differential diagnosis of bone tumours as well as in cases with central vestibular disease.
骨多叶状肿瘤（MTB）是一种罕见的肿瘤，通常位于颅骨。一只13岁的混血犬出现了为期两周的逐渐加重的前庭功能障碍和认知异常；它看起来痴呆，表现出不对称性共济失调和四肢辨距不良。主人选择对该动物实施安乐死。尸检发现一个大肿块占据了右枕骨、顶骨和颞骨，严重压迫小脑和右枕叶。组织学上，其特征是存在多个含有类骨质或软骨的小叶，并被纤维间隔隔开，这是MTB的典型特征。肺转移明显。据我们所知，这是第一例MTB导致严重脑和小脑压迫的报告，也是第二例枕骨MTB的详细报告。MTB应纳入骨肿瘤以及中枢性前庭疾病病例的鉴别诊断中。
