替利沙坦A、替利沙坦B和莱托花青碱的全合成。
Total syntheses of telisatin A, telisatin B and lettowianthine.
作者信息
Nimgirawath Surachai, Udomputtimekakul Phansuang
机构信息
Department of Chemistry, Faculty of Science, Silpakorn University; Nakorn Pathom 73000, Thailand.
出版信息
Molecules. 2009 Feb 26;14(3):917-24. doi: 10.3390/molecules14030917.
Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of these derivatives with tributyltin hydride and 1,1-azobis(cyclohexanecarbonitrile) afforded telisatin A, telisatin B and lettowianthine.
用草酰氯和三乙胺处理1-(2-溴芳基甲基)-3,4-二氢异喹啉，得到1-(2-溴苯基)-5,6-二氢吡咯并[2,1-a]异喹啉-2,3-二酮衍生物，例如1-(2-溴苯基)-5,6-二氢-8,9-二甲氧基吡咯并[2,1-a]异喹啉-2,3-二酮。这些衍生物与三丁基氢化锡和1,1-偶氮双(环己烷甲腈)进行自由基环化反应，得到特利沙坦A、特利沙坦B和莱托维安汀。
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