Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
作者信息
Kuo Reen-Yen, Wu Chin-Chung, Chang Fang-Rong, Yeh Jwu-Lai, Chen Ing-Jun, Wu Yang-Chang
机构信息
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
Bioorg Med Chem Lett. 2003 Mar 10;13(5):821-3. doi: 10.1016/s0960-894x(03)00003-9.
Abstract
Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.
摘要
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