Revest J-M, Dupret D, Koehl M, Funk-Reiter C, Grosjean N, Piazza P-V, Abrous D N
INSERM U862, Neurocenter Magendie, Pathophysiology of Addiction group, Bordeaux, France.
Mol Psychiatry. 2009 Oct;14(10):959-67. doi: 10.1038/mp.2009.15. Epub 2009 Mar 3.
Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.
成体海马神经发生是结构可塑性的一个独特例子，其功能作用一直是激烈争论的焦点。新的转基因模型最近表明，神经发生参与海马介导的学习。在这里，我们表明，成年海马神经发生被特异性损害的转基因动物表现出与焦虑相关行为的显著增加。我们的结果表明，神经发生在情感状态的调节中起重要作用，并且可能成为焦虑症新治疗方法的靶点。
