Zorlu Yunus, Ermeydan Mahmut Ali, Dumoulin Fabienne, Ahsen Vefa, Savoie Huguette, Boyle Ross W
Gebze Institute of Technology, Department of Chemistry, P.O. Box 141, Gebze, 41400, Kocaeli, Turkey.
Photochem Photobiol Sci. 2009 Mar;8(3):312-8. doi: 10.1039/b817348f. Epub 2009 Jan 14.
Three novel water soluble, non-ionic, zinc phthalocyanines (Pcs) have been synthesized and their spectroscopic and photodynamic properties investigated in aqueous media. One of the three compounds was shown to be significantly less aggregated, when compared to the other two compounds, and this effect was found to be related to both the nature of the substituent, and also the position at which it is attached to the macrocycle. Photodynamic activity and cellular uptake by human adenocarcinoma cells (HT-29) was shown to be linked to the aggregation state of the Pcs in water.
合成了三种新型水溶性、非离子型锌酞菁（Pcs），并在水性介质中研究了它们的光谱和光动力性质。与其他两种化合物相比，三种化合物中的一种显示出明显较少的聚集，并且发现这种效应与取代基的性质以及它连接到大环的位置有关。光动力活性和人腺癌细胞（HT-29）的细胞摄取显示与Pcs在水中的聚集状态有关。
