de Oliveira Marcos Roberto, Oliveira Max William Soares, Behr Guilherme Antônio, de Bittencourt Pasquali Matheus Augusto, Moreira José Cláudio Fonseca
Centro de Estudos em Estresse Oxidativo (Lab. 32), Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, rua Ramiro Barcelos, 2600-Anexo, Porto Alegre, RS, CEP 90035-003, Brazil.
Neurochem Res. 2009 Aug;34(8):1410-6. doi: 10.1007/s11064-009-9927-6. Epub 2009 Mar 3.
Vitamin A, beyond its biological role, is an alternative choice in treating some life threatening pathologies, for instance leukemia and immunodeficiency. On the other hand, vitamin A therapy at moderate to high doses has caused concern among public health researchers due to the toxicological aspect resulting from such habit. It has been described hepatotoxicity, cognitive disturbances and increased mortality rates among subjects ingesting increased levels of vitamin A daily. Then, based on the previously reported data, we investigated here receptor for advanced glycation endproducts (RAGE) immunocontent and oxidative damage levels in cerebral cortex of vitamin A-treated rats at clinical doses (1,000-9,000 IU/kg day(-1)). RAGE immunocontent, as well as oxidative damage levels, were observed increased in cerebral cortex of vitamin A-treated rats. Whether increased RAGE levels exert negative effects during vitamin A supplementation it remains to be investigated, but it is very likely that deleterious consequences may arise from such alteration.
维生素A除了其生物学作用外，还是治疗某些危及生命的病症（如白血病和免疫缺陷）的一种选择。另一方面，中高剂量的维生素A疗法因其产生的毒理学问题而引起了公共卫生研究人员的关注。据描述，每日摄入维生素A水平增加的受试者会出现肝毒性、认知障碍和死亡率上升。然后，基于先前报道的数据，我们在此研究了临床剂量（1000 - 9000 IU/kg·天⁻¹）维生素A处理的大鼠大脑皮层中晚期糖基化终产物受体（RAGE）的免疫含量和氧化损伤水平。在维生素A处理的大鼠大脑皮层中观察到RAGE免疫含量以及氧化损伤水平增加。维生素A补充期间RAGE水平升高是否会产生负面影响仍有待研究，但很可能这种改变会产生有害后果。
