Sutter T R, Guzman K, Dold K M, Greenlee W F
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
Science. 1991 Oct 18;254(5030):415-8. doi: 10.1126/science.1925598.
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1 beta. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation.
二噁英（2,3,7,8-四氯二苯并对二噁英，TCDD）是一种广泛存在的环境污染物，它可能通过改变易感细胞中的基因表达来引发其效应。从人角质形成细胞系中分离出了五个对TCDD有反应的互补DNA克隆。其中一个克隆编码纤溶酶原激活物抑制剂-2，该因子通过调节细胞外基质的蛋白水解来影响生长和分化。另一个克隆编码细胞因子白细胞介素-1β。因此，TCDD改变生长调节基因的表达，其作用类似于其他影响炎症和分化的促肿瘤剂。
