Laubie M, Schmitt H, Falq E
Eur J Pharmacol. 1977 Apr 7;42(3):307-10. doi: 10.1016/0014-2999(77)90299-0.
ET 495 and apomorphine, injected in small doses (0.1--1 microng/kg) into the femoral artery, induced a dose-dependent increase in femoral blood flow. This dilator effect was abolished by section of the ipsilateral femoral nerve and sciatic nerve, transection of the spinal cord, alpha-adrenoceptor blockade, ganglionic blockade and guanethidine. In addition, the increase in blood flow was inhibited by intravenous administration of haloperiol (2 mg/kg i.v.) or pimozide (2 mg/kg i.v.) and by injection of small doses (10--50 microng/kg) of these drugs into the femoral artery. It was concluded that a dopaminergic component located in the femoral vascular bed of the dog may be involved in the local vasodilator and sympathoinhibitory effect of apomorphine and ET 495.
将ET 495和阿扑吗啡以小剂量（0.1 - 1微克/千克）注入股动脉，可引起股血流量呈剂量依赖性增加。这种扩张效应可通过切断同侧股神经和坐骨神经、横断脊髓、α - 肾上腺素受体阻断、神经节阻断和胍乙啶来消除。此外，静脉注射氟哌啶醇（2毫克/千克静脉注射）或匹莫齐特（2毫克/千克静脉注射）以及向股动脉注射小剂量（10 - 50微克/千克）的这些药物可抑制血流量增加。得出的结论是，位于犬股血管床中的多巴胺能成分可能参与了阿扑吗啡和ET 495的局部血管舒张和交感神经抑制作用。
