麻醉犬静脉注射阿扑吗啡所产生的低血压并非由中枢介导。
Hypotension produced by intravenous apomorphine in the anaesthetized dog is not centrally mediated.
作者信息
Bogaert M G, Buylaert W A, Willems J L
出版信息
Br J Pharmacol. 1978 Jul;63(3):481-4. doi: 10.1111/j.1476-5381.1978.tb07801.x.
Abstract
1 Intravenous administration of apomorphine (1.25 to 20 microgram/kg) in the anaesthetized dog produced a dose-dependent decrease in blood pressure which was antagonized by haloperidol but not influenced by propranolol or atropine. 2 Intracarotid administration of apomorphine produced a systemic hypotension which was significantly smaller than that seen with intravenous injection. 3 Doses of apomorphine that caused a decrease in blood pressure on intravenous injection, had no effect on blood pressure or caused retching accompanied by an increase in blood pressure on intravertebral or intracisternal administration. The animals showed a marked hypotension on intravertebral or intracisternal injection of clonidine. 4 From these results it is concluded that the hypotension seen with intravenous apomorphine cannot be explained by a central site of action.
摘要
- 在麻醉犬中静脉注射阿扑吗啡（1.25至20微克/千克）可导致血压呈剂量依赖性下降，氟哌啶醇可拮抗此作用，但普萘洛尔或阿托品对此无影响。2. 颈内注射阿扑吗啡可引起全身性低血压，其程度明显小于静脉注射所见。3. 静脉注射时能引起血压下降的阿扑吗啡剂量，在经椎管或脑池内给药时对血压无影响或引起干呕并伴有血压升高。动物在经椎管或脑池内注射可乐定时出现明显低血压。4. 从这些结果可以得出结论，静脉注射阿扑吗啡时出现的低血压不能用中枢作用部位来解释。
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本文引用的文献
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Hypotensive effect of apomorphine in anesthetized cats.
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Cardiovascular and renal actions of dopamine: potential clinical applications.多巴胺的心血管和肾脏作用：潜在的临床应用
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Dopamine-like renal and mesenteric vasodilation caused by apomorphine 6-propylnorapomorphine and 2-amino-6, 7-dihydroxy-1,2,3,4-tetrahydronaphthalene.阿扑吗啡、6-丙基去甲阿扑吗啡和2-氨基-6,7-二羟基-1,2,3,4-四氢萘引起的多巴胺样肾和肠系膜血管舒张。
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Inhibition of the sympathetic nervous system by 5,6-dihydroxy-2-dimethylamino tetralin (M-7), apomorphine and dopamine.5,6-二羟基-2-二甲基氨基四氢萘（M-7）、阿扑吗啡和多巴胺对交感神经系统的抑制作用
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