来自内生烟曲霉的生物活性生物碱。

Bioactive alkaloids from endophytic Aspergillus fumigatus.

作者信息

Ge Hui Ming, Yu Zhi Guo, Zhang Jie, Wu Jun Hua, Tan Ren Xiang

机构信息

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.

出版信息

J Nat Prod. 2009 Apr;72(4):753-5. doi: 10.1021/np800700e.

DOI:10.1021/np800700e

PMID:19256529

Abstract

Two new alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 known compounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity against human leukemia cells (K562) with an IC(50) value of 3.1 microM, which was comparable to that of doxorubicin hydrochloride, a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration.

摘要

从烟曲霉培养物中分离出两种新生物碱，分别命名为9-去乙酰基烟曲霉棒曲霉素C（1）和9-去乙酰氧基烟曲霉棒曲霉素C（2），以及12种已知化合物（3 - 14）。通过综合光谱分析阐明了新化合物的结构。化合物2对人白血病细胞（K562）表现出选择性强效细胞毒性，IC50值为3.1微摩尔，这与目前用于治疗白血病的处方药盐酸多柔比星相当。此外，14-去甲异麦角甾苷（4）在浓度为10.0微摩尔时显著诱导大鼠嗜铬细胞瘤细胞（PC12）的神经突生长。