Ge Hui Ming, Yu Zhi Guo, Zhang Jie, Wu Jun Hua, Tan Ren Xiang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.
J Nat Prod. 2009 Apr;72(4):753-5. doi: 10.1021/np800700e.
Two new alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 known compounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity against human leukemia cells (K562) with an IC(50) value of 3.1 microM, which was comparable to that of doxorubicin hydrochloride, a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration.
从烟曲霉培养物中分离出两种新生物碱，分别命名为9-去乙酰基烟曲霉棒曲霉素C（1）和9-去乙酰氧基烟曲霉棒曲霉素C（2），以及12种已知化合物（3 - 14）。通过综合光谱分析阐明了新化合物的结构。化合物2对人白血病细胞（K562）表现出选择性强效细胞毒性，IC50值为3.1微摩尔，这与目前用于治疗白血病的处方药盐酸多柔比星相当。此外，14-去甲异麦角甾苷（4）在浓度为10.0微摩尔时显著诱导大鼠嗜铬细胞瘤细胞（PC12）的神经突生长。
