植物内生真菌来源的抗老年痴呆天然产物。

Anti-Alzheimer's Natural Products Derived from Plant Endophytic Fungi.

机构信息

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Center for Medical Device Evaluation, National Medical Products Administration, Beijing 100081, China.

出版信息

Molecules. 2023 Feb 28;28(5):2259. doi: 10.3390/molecules28052259.

DOI:10.3390/molecules28052259

PMID:36903506

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005758/

Abstract

Alzheimer's is the most common cause of dementia worldwide and seriously affects patients' daily tasks. Plant endophytic fungi are known for providing novel and unique secondary metabolites with diverse activities. This review focuses primarily on the published research regarding anti-Alzheimer's natural products derived from endophytic fungi between 2002 and 2022. Following a thorough review of the literature, 468 compounds with anti-Alzheimer's-related activities are reviewed and classified based on their structural skeletons, primarily including alkaloids, peptides, polyketides, terpenoids, and sterides. The classification, occurrences, and bioactivities of these natural products from endophytic fungi are summarized in detail. Our results provide a reference on endophytic fungi natural products that may assist in the development of new anti-Alzheimer's compounds.

摘要

阿尔茨海默病是全球最常见的痴呆症病因，严重影响患者的日常任务。植物内生真菌以提供具有多种活性的新型独特次生代谢产物而闻名。本综述主要关注 2002 年至 2022 年间发表的关于源自内生真菌的抗阿尔茨海默病天然产物的研究。在对文献进行彻底审查后，综述了具有抗阿尔茨海默病相关活性的 468 种化合物，并根据其结构骨架进行了分类，主要包括生物碱、肽、聚酮、萜类和甾类。详细总结了这些内生真菌天然产物的分类、存在和生物活性。我们的研究结果为内生真菌天然产物提供了参考，可能有助于开发新的抗阿尔茨海默病化合物。