Verkruysse Wim, Svaasand Lars O, Franco Walfre, Nelson J Stuart
University of California, Irvine Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA.
J Biomed Opt. 2009 Jan-Feb;14(1):014005. doi: 10.1117/1.3065542.
Objective quantification of epidermal melanin concentration (EMC) should be useful in laser dermatology to determine the individual maximum safe radiant exposure (IMSRE). We propose a single-wavelength remittance measurement at 390 nm as an alternative optical method to determine EMC and IMSRE. Remittance spectra (360 to 740 nm), melanin index (MI) measurements and the transient radiometric temperature increase, DeltaT(t), upon skin irradiation with an Alexandrite laser (755 nm, 3-ms pulse duration, 6 Jcm(2)) were measured on 749 skin spots (arm and calf) on 23 volunteers (skin phototypes I to IV). Due to the shallow penetration depth and independence of blood oxygen saturation (isosbestic point), remittance at 390 nm appears to provide better estimates for EMC and IMSRE than MI.
在激光皮肤科中,对表皮黑色素浓度(EMC)进行客观量化有助于确定个体最大安全辐射暴露量(IMSRE)。我们提出在390nm处进行单波长反射测量,作为确定EMC和IMSRE的一种替代光学方法。在23名志愿者(皮肤光型I至IV)的749个皮肤部位(手臂和小腿)上,测量了反射光谱(360至740nm)、黑色素指数(MI),以及在用翠绿宝石激光(755nm,3ms脉冲持续时间,6J/cm²)照射皮肤时的瞬态辐射温度升高ΔT(t)。由于穿透深度较浅且与血氧饱和度无关(等吸收点),390nm处的反射似乎比MI能更好地估计EMC和IMSRE。