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多直径单纤维反射光谱法在重度色素沉着皮肤中的应用：对黑色素不均匀分布的建模。

Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin.

机构信息

Amsterdam UMC, University of Amsterdam, Department of Biomedical Engineering and Physics, Amsterdam, The Netherlands.

Amsterdam UMC, Cancer Center Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

出版信息

J Biomed Opt. 2019 Dec;24(12):1-11. doi: 10.1117/1.JBO.24.12.127001.

DOI:10.1117/1.JBO.24.12.127001
PMID:31820596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7006040/
Abstract

When analyzing multidiameter single-fiber reflectance (MDSFR) spectra, the inhomogeneous distribution of melanin pigments in skin tissue is usually not accounted for. Especially in heavily pigmented skins, this can result in bad fits and biased estimation of tissue optical properties. A model is introduced to account for the inhomogeneous distribution of melanin pigments in skin tissue. visible MDSFR measurements were performed on heavily pigmented skin of type IV to VI. Skin tissue optical properties and related physiological properties were extracted from the measured spectra using the introduced model. The absorption of melanin pigments described by the introduced model demonstrates a good correlation with the co-localized measurement of the well-known melanin index.

摘要

在分析多直径单光纤反射（MDSFR）光谱时，通常不会考虑皮肤组织中黑色素颜料的不均匀分布。特别是在色素沉着严重的皮肤中，这可能导致拟合效果不佳和组织光学特性的估计出现偏差。本文引入了一种模型来解释皮肤组织中黑色素颜料的不均匀分布。对 IV 至 VI 型色素沉着严重的皮肤进行了可见 MDSFR 测量。使用引入的模型从测量的光谱中提取皮肤组织光学特性和相关生理特性。引入模型中描述的黑色素颜料吸收与众所周知的黑色素指数的共定位测量具有很好的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/9579fe4c2dee/JBO-024-127001-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/bcadfca567da/JBO-024-127001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/b41580d804b6/JBO-024-127001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/5091e0187f3f/JBO-024-127001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/2888d2b8c558/JBO-024-127001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/145931118377/JBO-024-127001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/d4c0585ce189/JBO-024-127001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/577fbed25192/JBO-024-127001-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/4c20dc3c3777/JBO-024-127001-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/9579fe4c2dee/JBO-024-127001-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/bcadfca567da/JBO-024-127001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/b41580d804b6/JBO-024-127001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/5091e0187f3f/JBO-024-127001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/2888d2b8c558/JBO-024-127001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/145931118377/JBO-024-127001-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/d4c0585ce189/JBO-024-127001-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/577fbed25192/JBO-024-127001-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/4c20dc3c3777/JBO-024-127001-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0698/7006040/9579fe4c2dee/JBO-024-127001-g009.jpg

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