Boonlikit Sathone
Department of Obstetrics and Gynecology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):715-8.
To determine the prevalence of high-grade cervical lesion (CIN 2 or worse, CIN 2+) and the prevalence of invasive cancers in women with LSIL, HSIL and positive for malignancy on cytology, respectively.
A retrospective study of patients undergoing colposcopy in Rajavithi hospital between 2003-2004 was performed. The final diagnosis was based on colposcopy and histology.
Among 250 women with LSIL and 152 women with HSIL, 28 (11.2%) and 112 (75.7%), respectively, had histology-confirmed high-grade cervical lesions. Invasive cancer was diagnosed in 12 (7.9%) of women with HSIL but in none of the LSIL cases. Among 19 women with positive smears for malignancy, only 7 ( 36.8 %) had histology-confirmed invasive cancer.
The present study confirms that women with HSIL have high prevalence of high-grade cervical lesions and malignancy. Women with LSIL may be managed less aggressively because of the negligible risk of more advanced lesions. Smears positive for malignancy are inconsistent predictors of invasive cancer.
分别确定低度鳞状上皮内病变（LSIL）、高度鳞状上皮内病变（HSIL）以及细胞学检查恶性阳性的女性中高级别宫颈病变（CIN 2或更严重，CIN 2+）的患病率和浸润性癌症的患病率。
对2003年至2004年在拉贾维提医院接受阴道镜检查的患者进行回顾性研究。最终诊断基于阴道镜检查和组织学检查。
在250例LSIL女性和152例HSIL女性中，分别有28例（11.2%）和112例（75.7%）经组织学证实为高级别宫颈病变。12例（7.9%）HSIL女性被诊断为浸润性癌症，而LSIL病例中无一例被诊断为浸润性癌症。在19例涂片检查恶性阳性的女性中，只有7例（36.8%）经组织学证实为浸润性癌症。
本研究证实，HSIL女性中高级别宫颈病变和恶性肿瘤的患病率较高。由于进展为更高级别病变的风险可忽略不计，LSIL女性的治疗可能不那么积极。涂片检查恶性阳性并不能一致地预测浸润性癌症。
