Saakian D B
Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Dec;78(6 Pt 1):061920. doi: 10.1103/PhysRevE.78.061920. Epub 2008 Dec 22.
The evolution model with parallel mutation-selection scheme is solved for the case when selection is accompanied by base substitutions, insertions, and deletions. The fitness is assumed to be either a single-peak function (i.e., having one finite discontinuity) or a smooth function of the Hamming distance from the reference sequence. The mean fitness is calculated exactly in large-genome limit. In the case of insertions and deletions the evolution characteristics depend on the choice of reference sequence.
针对选择过程伴有碱基替换、插入和缺失的情况，求解了具有并行突变 - 选择方案的进化模型。适应度被假定为要么是单峰函数（即有一个有限间断点），要么是与参考序列的汉明距离的光滑函数。在大基因组极限情况下精确计算了平均适应度。在插入和缺失的情况下，进化特征取决于参考序列的选择。
