Noise-assisted spike propagation in myelinated neurons.

We consider noise-assisted spike propagation in myelinated axons within a multicompartment stochastic Hodgkin-Huxley model. The noise originates from a finite number of ion channels in each node of Ranvier. For the subthreshold internodal electric coupling, we show that (i) intrinsic noise removes the sharply defined threshold for spike propagation from node to node and (ii) there exists an optimum number of ion channels which allows for the most efficient signal propagation and it corresponds to the actual physiological values.