Proença-Modena José Luiz, Acrani Gustavo Olszanski, Brocchi Marcelo
Department of Cell & Molecular Biology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Future Microbiol. 2009 Mar;4(2):223-40. doi: 10.2217/17460913.4.2.223.
Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes the gastric mucus overlying the epithelium of the stomach in more than 50% of the world's population. This gastric colonization induces chronic gastric inflammation in all infected individuals, but only induces clinical diseases in 10-20% of infected individuals. These include peptic ulcers, acute and atrophic gastritis, intestinal metaplasia, gastric adenocarcinoma and gastric B-cell lymphoma. Various bacterial virulence factors are associated with the development of such gastric diseases, and the characterization of these markers could aid medical prognosis, which could be extremely important in predicting clinical outcomes. The purpose of this review is to summarize the role of the phenotypes, virulence-related genes and genotypes of H. pylori in the establishment of gastric colonization and the development of associated diseases.
幽门螺杆菌是一种革兰氏阴性、微需氧菌，全球超过50%的人口胃上皮表面的胃黏液中都有它的定植。这种胃部定植会在所有感染者中引发慢性胃部炎症，但只有10%-20%的感染者会出现临床疾病。这些疾病包括消化性溃疡、急慢性萎缩性胃炎、肠化生、胃腺癌和胃B细胞淋巴瘤。多种细菌毒力因子与这些胃部疾病的发生有关，对这些标志物的特性进行鉴定有助于医学预后判断，这对预测临床结果可能极为重要。本综述的目的是总结幽门螺杆菌的表型、毒力相关基因和基因型在胃部定植及相关疾病发生过程中的作用。
