Meecham J G, Thomson C W, Blair G S
Department of Oral Surgery, Dental School, Newcastle upon Tyne.
SAAD Dig. 1991 Apr;8(1-2):19-25.
A model has been developed which permits the investigation of the systemic effects of adrenaline injected during dental local anesthesia. The model employs patients undergoing the removal of third molars under general anaesthesia. This design allows the study of the effects of exogenous adrenaline administration in clinical doses in patients experiencing surgical stress. In the present investigation the influence of the intra-oral injection of 50 micrograms adrenaline contained in lignocaine local anaesthetic solution on haemodynamic and biochemical responses was established by comparing the effects of inferior alveolar block injections of 4 ml 2% lignocaine and 4 ml 2% lignocaine with 1:80,000 adrenaline in 20 patients having third molars removed with a standardised general anaesthetic regime. No significant changes in haemodynamic responses between treatments were apparent, however significant changes occurred between treatments in blood glucose and plasma potassium levels.
已经开发出一种模型，可用于研究牙科局部麻醉期间注射肾上腺素的全身效应。该模型采用在全身麻醉下拔除第三磨牙的患者。这种设计允许在经历手术应激的患者中研究临床剂量的外源性肾上腺素给药的效果。在本研究中，通过比较20例接受标准化全身麻醉方案拔除第三磨牙的患者，在下牙槽阻滞注射4ml 2%利多卡因和4ml含1:80,000肾上腺素的2%利多卡因后对血流动力学和生化反应的影响，确定了利多卡因局部麻醉溶液中50微克肾上腺素口腔内注射的影响。治疗之间血流动力学反应没有明显变化，然而治疗之间血糖和血钾水平发生了显著变化。
