Kim Young S, Young Matthew R, Bobe Gerd, Colburn Nancy H, Milner John A
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA.
Cancer Prev Res (Phila). 2009 Mar;2(3):200-8. doi: 10.1158/1940-6207.CAPR-08-0141. Epub 2009 Mar 3.
Various dietary components may modify chronic inflammatory processes at the stage of cytokine production, amplification of nuclear factor-kappaB-mediated inflammatory gene expression, and the release of anti-inflammatory cytokine, transforming growth factor-beta. This review provides a synopsis of the strengths and weaknesses of the evidence that specific bioactive food components influence inflammation-related targets linked to cancer. A target repeatedly surfacing as a site of action for several dietary components is transforming growth factor beta. Whereas the use of dietary intervention strategies offers intriguing possibilities for maintaining normal cell function by modifying a process that is essential for cancer development and progression, more information is needed to characterize the minimum quantity of the bioactive food components required to bring about a change in inflammation-mediated cancer, the ideal time for intervention, and the importance of genetics in determining the response. Unquestionably, the societal benefits of using foods and their components to prevent chronic inflammation and associated complications, including cancer, are enormous.
多种饮食成分可能在细胞因子产生阶段、核因子-κB介导的炎症基因表达放大以及抗炎细胞因子转化生长因子-β释放阶段改变慢性炎症过程。本综述概述了特定生物活性食品成分影响与癌症相关的炎症相关靶点的证据的优缺点。作为几种饮食成分作用位点反复出现的一个靶点是转化生长因子β。虽然饮食干预策略通过改变对癌症发生和发展至关重要的过程为维持正常细胞功能提供了有趣的可能性，但需要更多信息来确定引起炎症介导的癌症变化所需的生物活性食品成分的最小量、理想的干预时间以及遗传学在确定反应中的重要性。毫无疑问，利用食物及其成分预防慢性炎症和相关并发症（包括癌症）的社会效益是巨大的。
