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虾青素对氧化应激的保护作用：减轻 TNF-α 诱导的 SW480 细胞氧化损伤和 AOM/DSS 诱导的 C57BL/6 小鼠结肠炎相关癌症。

Protective Effects of Astaxanthin against Oxidative Stress: Attenuation of TNF-α-Induced Oxidative Damage in SW480 Cells and Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in C57BL/6 Mice.

机构信息

College of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China.

Engineering Research Center for Huaiyang Cuisine of Jiangsu Province, Yangzhou 225127, China.

出版信息

Mar Drugs. 2024 Oct 12;22(10):469. doi: 10.3390/md22100469.

DOI:10.3390/md22100469
PMID:39452878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11509176/
Abstract

In this study, we investigated the protective effects of astaxanthin (AST) against oxidative stress induced by the combination of azoxymethane (AOM) and dextran sulfate sodium (DSS) in colitis-associated cancer (CAC) and TNF-α-induced human colorectal cancer cells (SW480), as well as the underlying mechanism. In vitro experiments revealed that astaxanthin reduced reactive oxygen species (ROS) generation and inhibited the expression of Phosphorylated JNK (P-JNK), Phosphorylated ERK (P-ERK), Phosphorylated p65 (P-p65), and the NF-κB downstream protein cyclooxygenase-2 (COX-2). In vivo experiments showed that astaxanthin ameliorated AOM/DSS-induced weight loss, shortened the colon length, and caused histomorphological changes. In addition, astaxanthin suppressed cellular inflammation by modulating the MAPK and NF-κB pathways and inhibiting the expression of the proinflammatory cytokines IL-6, IL-1β, and TNF-α. In conclusion, astaxanthin attenuates cellular inflammation and CAC through its antioxidant effects.

摘要

在这项研究中，我们研究了虾青素（AST）对氧化应激的保护作用，这种氧化应激是由氧化偶氮甲烷（AOM）和葡聚糖硫酸钠（DSS）联合诱导的，其作用对象为结肠炎相关癌症（CAC）和肿瘤坏死因子-α诱导的人结肠癌细胞（SW480），以及其潜在机制。体外实验表明，虾青素减少了活性氧（ROS）的产生，并抑制了磷酸化 JNK（P-JNK）、磷酸化 ERK（P-ERK）、磷酸化 p65（P-p65）和 NF-κB 下游蛋白环氧化酶-2（COX-2）的表达。体内实验表明，虾青素改善了 AOM/DSS 诱导的体重减轻、缩短了结肠长度，并引起了组织形态学的变化。此外，虾青素通过调节 MAPK 和 NF-κB 通路和抑制促炎细胞因子 IL-6、IL-1β和 TNF-α的表达，抑制了细胞炎症。总之，虾青素通过其抗氧化作用减轻了细胞炎症和 CAC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/470b11e06942/marinedrugs-22-00469-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/f303e070ceee/marinedrugs-22-00469-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/94e274a9debd/marinedrugs-22-00469-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/466ae1d7c6a0/marinedrugs-22-00469-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/1fa014e99c7b/marinedrugs-22-00469-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/533ce05d86ad/marinedrugs-22-00469-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/098943babfdc/marinedrugs-22-00469-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/470b11e06942/marinedrugs-22-00469-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/f303e070ceee/marinedrugs-22-00469-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/94e274a9debd/marinedrugs-22-00469-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/466ae1d7c6a0/marinedrugs-22-00469-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/1fa014e99c7b/marinedrugs-22-00469-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/533ce05d86ad/marinedrugs-22-00469-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/098943babfdc/marinedrugs-22-00469-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/add8/11509176/470b11e06942/marinedrugs-22-00469-g007.jpg

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Protective Effects of Astaxanthin against Oxidative Stress: Attenuation of TNF-α-Induced Oxidative Damage in SW480 Cells and Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in C57BL/6 Mice.

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引用本文的文献

[1]
Astaxanthin promotes apoptosis by suppressing growth signaling pathways in HT-29 colorectal cancer cells.

Med Oncol. 2025-8-12

[2]
Microalgae Bioactives for Functional Food Innovation and Health Promotion.

Foods. 2025-6-17

[3]
Astaxanthin: A Compound in the Prevention of Chronic Diseases and as a Potential Adjuvant Treatment Agent.

Antioxidants (Basel). 2025-6-12

本文引用的文献

[1]
Protective Role of Astaxanthin in Regulating Lipopolysaccharide-Induced Inflammation and Apoptosis in Human Neutrophils.

Curr Issues Mol Biol. 2024-8-5

[2]
Sustained-release of SOD from multivesicular liposomes accelerated the colonic mucosal healing of colitis mice by inhibiting oxidative stress.

Colloids Surf B Biointerfaces. 2024-11

[3]
Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders.

Plants (Basel). 2024-6-7

[4]
Generation of Porcine and Rainbow Trout 3D Intestinal Models and Their Use to Investigate Astaxanthin Effects In Vitro.

Int J Mol Sci. 2024-5-29

[5]
Isorhamnetin alleviates ferroptosis-mediated colitis by activating the NRF2/HO-1 pathway and chelating iron.

Int Immunopharmacol. 2024-6-30

[6]
Fmp40 ampylase regulates cell survival upon oxidative stress by controlling Prx1 and Trx3 oxidation.

Redox Biol. 2024-7

[7]
Resveratrol targeting NRF2 disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage in mice pulmonary infection.

J Ethnopharmacol. 2024-10-5

[8]
ROS-responsive carboxymethyl chitosan nanoparticles loaded with astaxanthin for alleviating oxidative damage in intestinal cells.

Colloids Surf B Biointerfaces. 2024-7

[9]
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.

ACS Nano. 2024-5-28

[10]
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.

Sci Total Environ. 2024-7-10

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