National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
China Academy of Chinese Medical Sciences, Xiyuan Hospital Suzhou Hospital, Suzhou, China.
Front Immunol. 2024 Apr 3;15:1380493. doi: 10.3389/fimmu.2024.1380493. eCollection 2024.
Hypertension is one of the major risk factors for cardiovascular disease. Dietary flavonoids have been reported to reduce inflammation, protect against oxidative stress, protect the vascular endothelium, and improve vascular health. However, the relationship between dietary flavonoid intake and the prevalence of hypertension remains controversial.
This study included 8010 adults from the 2007-2010 and 2017-2018 National Health and Nutrition Examination Surveys (NHANES). The relationship between dietary flavonoid intake and the prevalence of hypertension was explored by weighted logistic regression and weighted restricted cubic spline.
We found an inverse relationship between total anthocyanin intake and the prevalence of hypertension in the fourth quartile compared with the first quartile [0.81(0.66,0.99), p = 0.04]. Moreover, the prevalence of hypertension tended to decrease with increasing total anthocyanin intake in participants over 60 years of age. In addition, we found a U-shaped relationship between the prevalence of hypertension and total flavan-3-ol intake. Total flavan-3-ol intake was inversely associated with hypertension prevalence in the third quartile compared with the first quartile [0.79 (0.63,0.99), p = 0.04]. Moreover, there was a significant negative association between the prevalence of hypertension and total flavan-3-ol intake when total flavan-3-ol intake was below 48.26 mg/day.
Our study found a negative association between the prevalence of hypertension and moderate total anthocyanins intake and total flavan-3-ols intake. Our study provides evidence from a population-based study for a negative association between dietary flavonoid intake and the prevalence of hypertension.
高血压是心血管疾病的主要危险因素之一。已报道膳食类黄酮可减少炎症、对抗氧化应激、保护血管内皮并改善血管健康。然而，膳食类黄酮的摄入量与高血压的患病率之间的关系仍存在争议。
本研究纳入了 2007-2010 年和 2017-2018 年全国健康和营养调查（NHANES）中的 8010 名成年人。采用加权逻辑回归和加权限制立方样条分析膳食类黄酮摄入量与高血压患病率之间的关系。
我们发现，与第一四分位相比，第四四分位的总花青素摄入量与高血压的患病率呈负相关[0.81（0.66，0.99），p=0.04]。此外，在 60 岁以上的参与者中，随着总花青素摄入量的增加，高血压的患病率呈下降趋势。此外，我们发现高血压的患病率与总黄烷-3-醇摄入量之间呈 U 形关系。与第一四分位相比，第三四分位的总黄烷-3-醇摄入量与高血压的患病率呈负相关[0.79（0.63，0.99），p=0.04]。此外，当总黄烷-3-醇摄入量低于 48.26mg/天时，高血压的患病率与总黄烷-3-醇摄入量之间存在显著的负相关关系。
本研究发现，高血压的患病率与中等水平的总花青素和总黄烷-3-醇摄入量呈负相关。本研究从基于人群的研究中提供了证据，证明膳食类黄酮的摄入量与高血压的患病率之间存在负相关。
